Leon D. Lotter
Physician Scientist in Integrative Neuroimaging & Psychiatry

Research

I want to understand what in vivo brain imaging measures biologically. I relate imaging findings – in typical development and in psychiatric disorders – to maps of the brain's molecular and cellular makeup, from neurotransmitter systems to gene expression, and I develop open tools for this, such as NiSpace. My goal is a methodological gold standard for such spatial correlation analyses – validated methods, and the reference maps of known biology they depend on.

Selected Preprints

Linking human brain functional connectivity to underlying neurotransmission

Lotter LD, Shafiei G, Larabi D, Koushik A, Dipasquale O, ..., Koenig J, Patil KR, Paquola C, Eickhoff SB, Dukart J (2026). bioRxiv.

Selected Publications

Methodological considerations: integrating measures across assessment modalities

Lotter LD, Dukart J (2025). Book chapter in: Neurobehavioral Individual Differences (Springer).

Regional patterns of human cortex development correlate with underlying neurobiology

Lotter LD, Saberi A, Hansen JY, Misic B, Paquola C, ..., IMAGEN Consortium, Nees F, Banaschewski T, Eickhoff SB, Dukart J (2024). Nature Communications.

Temporal dissociation between local and global functional adaptations of the maternal brain to childbirth - A longitudinal assessment

Lotter LD, Nehls S, Losse E, Dukart J, Chechko N (2024). Neuropsychopharmacology.

Revealing the neurobiology underlying interpersonal neural synchronization with multimodal data fusion

Lotter LD, Kohl SH, Gerloff C, Bell L, Niephaus A, Kruppa JA, Dukart J, Schulte-Rüther M, Reindl V, Konrad K (2023). Neuroscience & Biobehavioral Reviews.

Recovery-Associated Resting-State Activity and Connectivity Alterations in Anorexia Nervosa

Lotter LD, von Polier G, Offermann J, Buettgen K, Stanetzky L, Eickhoff SB, Konrad K, Seitz J*, & Dukart J* (2021). Biological Psychiatry - Cognitive Neuroscience and Neuroimaging.

The many-to-many problem of endophenotypes in psychiatry - a biological perspective

Dukart J, Lotter LD, Paquola C, Eickhoff SB, Schilbach L (2026). Molecular Psychiatry.

Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling

Saberi A, Wischnewski KJ, Jung K, Lotter LD, ..., Popovych OV, Eickhoff SB, Valk SL (2025). Science Advances.

Beware 'persuasive communication devices' when writing and reading scientific articles

Corneille O, Havemann J, Henderson EL, Ijzerman H, Hussey I, Orban de Xivry J, Jussim L, Holmes NP, Pilacinski A, Beffara B, Carroll H, Outa NO, Lush P, Lotter LD (2023). eLife.

*shared authorships

Software

About Me

Portrait @ Nikolaus Brade

I am a physician scientist working at the intersection of neuroimaging and the molecular and cellular biology of the human brain. I trained in medicine at RWTH Aachen University and obtained my doctorate (Dr. med.) with a thesis on resting-state functional MRI in anorexia nervosa.

I am a research associate at the Institute of Neuroscience and Medicine: Brain and Behaviour (INM-7), Forschungszentrum Jülich, and the Institute of Systems Neuroscience, University Hospital Düsseldorf, where I work in Jürgen Dukart's Biomarker Development Group. Alongside, I am completing an additional PhD in the Clinician Scientist Program of the Max Planck School of Cognition.